This study provides data on the performed synthesis of Metal-organic framework MIL-101(Cr) nanostructure through the application of a hydrothermal method. The prepared catalysts were characterized by the means of FESEM/ EDAX/PSA, FTIR, UV-Vis, BET, and XRD analyses. As the obtained XRD pattern approved the synthesis of MIL-101(Cr) by displaying diffraction peaks, the FESEM images also demonstrated the octahedral construction of this product. In addition, we evaluated the photocatalytic functionality and adsorption of MIL-101(Cr) for degrading methylene blue (MB) dye under UV light and dark conditions, respectively. According to the results, this product displayed an excellent potential for the removal of organic pollutants from aqueous solutions. However, the best outcomes were attained through the sonication method, since the structure and degradation properties of particles were improved due to the usage of chemical sonic.