Comparative study on the effect of transition metal (Zn2+) and alkaline earth metal (Mg2+) ions on adsorption-release of diclofenac and ibuprofen on nano M-Al-LDH as drug carriers

Document Type : Research Paper

Authors

Department of Chemistry, Payame Noor University (PNU), P.O. Box: 19395-3697, Tehran, Iran

10.22036/icr.2021.282596.1106

Abstract

In this project, three nanoscale M-Al LDHs, which M is a divalent metal (Mg2+, Zn2+ and/or a mixture of them and LDH = Layered Double Hydroxide) were synthesized by co-precipitation and characterized by general techniques, such as FTIR, XRD, FESEM, and EDS. LDHs have got different physical properties, such as; crystal size, lattice parameters, morphology and drug delivery. These M-Al LDHs were used as drug carriers for diclofenac and ibuprofen, which adsorption and release percentages of drugs by them were studied and compared. The results showed that Al-LDHs including transition metal (Zn2+) are suitable for drug delivery purposes. As the mixed divalent (Zn/Mg)-Al LDHs are more efficient drug carriers for both diclofenac and ibuprofen drugs.

Graphical Abstract

Comparative study on the effect of transition metal (Zn2+) and alkaline earth metal (Mg2+) ions on adsorption-release of diclofenac and ibuprofen on nano M-Al-LDH as drug carriers

Keywords

Volume 5, Issue 2
December 2021
Pages 207-214
  • Receive Date: 01 June 2021
  • Revise Date: 05 August 2021
  • Accept Date: 06 August 2021