Document Type : Research Paper

Authors

• Sara Eavani
• Ehsan Azadi
• Mohammad Joshaghani

Faculty of Chemistry, Razi University, Kermanshah, Iran

Abstract

Catalytic activity of a Pd/biphenyl based- phosphine system in the Ullmann cross-coupling reaction of various para-substituted aryl bromides were investigated. The results showed that the bulky electron-rich phosphine efficiently modify the electronic and steric properties of palladium center and promote the cross-coupling reaction. Mechanistic study using the Hammett correlation revels that electron-withdrawing substituents decrease the electron density at the palladium center and decrease the rate of oxidative-addition step such that this step will become the rate determining step (rds). On the other hand, electron-donating groups increase the rate of oxidative-addition step such that the reductive-elimination step will become the rds.

Keywords

• Ullmann cross-coupling
• Palladium catalyst
• Phosphine
• Hammett correlation
• Mechanistic study