The synthesis routes for the preparation of nanostructures have been developed in the past decade. Organometallic precursors played an important role in the synthesis of nanomaterials via various methods of synthesis. In this investigation, nanostructures were synthesized from organometallic precursors and applied as catalyst in various reactions. This mini review is mostly devoted to the research efforts carried out by our group on the search for new classes of organometallic precursors and applying them for the synthesis of nanostructured catalysts with different morphologies. Also we have investigated the effect of alloying and presence of support on catalytic activity. We found that stabilization of nanostructures on graphene oxide, aminoclay, ionic liquids or cyclodextrin supports can increase the catalytic activity by increasing the stability and dispersion. Furthermore, alloyed nanostructures can be efficient like noble metal catalysts in catalytic applications. Also, thin films fabricated by this method showed higher quality in comparison with the thin films fabricated by other synthetic methods.